Animal house facility, Tatyasaheb Kore College of Pharmacy, Warananagar

Animal House Facility

Vision:

To become a centre of excellence in preclinical research

Mission:

To accomplish animal studies crucial in drug discovery and development in most human way following guidelines of CPCSEA

Animal House Facility (AHF) at Tatyasaheb Kore College of Pharmacy, Warananagar was established in 2007 to accomplish the requirements of various investigators from different departments in Tatyasaheb Kore College of Pharmacy, Warananagar. AHF is registered with the committee for the purpose of control and supervision of experiments on animals (CPCSEA), Ministry of Environment and Forests, Government of India, New Delhi (Registration Number: 1090/Po/Re/S/07/CPCSEA All activities associated with laboratory animal research at Animal House Facility (AHF) at Tatyasaheb Kore College of Pharmacy, Warananagar are performed as per the guidelines of CPCSEA, New Delhi as well as institutional guidelines under the supervision of Institutional Animal Ethics Committee (IAEC).

Animal House Facility (AHF) at Tatyasaheb Kore College of Pharmacy, Warananagar is located in a secluded corner of the campus, away from noise and pollution, providing an excellent environment for animals. The facility is equipped for small animal experimentation with quarantine and experimental rooms for rodents and rabbits. The Animal House is a conventional type of animal house with each species housed in individual rooms, in which the temperature, humidity, dark, and light cycles are monitored. The animal species are being used for various research projects approved by the Institutional Animal Ethics Committee (IAEC). The health status of the animals is being monitored by a Veterinary Doctor.

IAEC Members

Name	Designation
Dr. J. I. Disouza	Chairman
Dr. A. S. Manjappa	Scientist from different biological discipline
Mr. M. V. Shinde	Scientist from different biological discipline
Mr. A. B. Patil	Scientist In charge of Animal House Facility, Member Secretary
Dr. V. R. Aralelimath	Main Nominee
Dr. S. B. Patil	Link Nominee
Dr. A. J. Patil	Scientist from outside the Institute
Dr. S. D. Bhinge	Socially Aware Nominee
Dr. J. B. Patil	Veterinarian

The animal house facility is available to conduct preclinical research including pharmacodynamic, pharmacokinetic studies including toxicity testing. Qualified veterinarian and technical personnel are always at hand to help carry out research and keep it in accordance with the standards established by the Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA).

The CPCSEA approved animal house for rats, mice, guinea pigs and rabbits with all facilities and frogery for housing frogs is available. The animal studies that are carried includes;

Antioxidant Studies:

Formulation, characterization and evaluation of liposomes loaded with bioflavonoid and tryptamine derivative for antioxidant activity
Isolation Characterization and hepatoprotective and antioxidant activity from a plant of Cucurbitaceae family
Isolation, Characterization & evaluation of hepatoprotective & antioxidant activity from the plant curcubitaceae
Formulation, Characterization & evaluation of liposomes loaded with biflavonoid and tryptamine derivative for antioxidant activity
Phytochemical investigation and evaluation of anticancer activity of Adenoon indicum L. leaves

Analgesic, Anti-inflammatory Studies:

Evaluation of analgesic activity of the herbal formulation
Development of novel topical gel formulation containing Hamiltonia surveolens for wound healing activity
Phytochemical investigation and evaluation of anticancer activity of Adenoon indicum L. leaves
Preparation and evaluation of new polyherbal formulation for their wound healing activity
Development of topical formulation containing Allophyllus cobbe L. for wound healing activity
Investigation of antiarthritic potential of Annona squamosa and Citrus sinensis
Phytochemical investigation of eleusine species for possible biological activities
Evaluation of anti-inflammatory and analgesic activity of the synthetic formulation
Modification of physicochemical properties of active pharmaceutical ingredients by crystal engineering (analgesic & anti-inflammatory)
Evaluation of anti-inflammatory activity of the herbal formulation
Evaluation of analgesic activity of the herbal formulation
Development and studies on in-vitro, in-vivo correlation of polyhydroxybutyrate based extended release tablet Ibuprofen
Development and studies in in-vitro, in-vivo correlation of new soft gelatin capsule containing oil-in-oil emulsion of Ibuprofen

Anti-diabetics Studies:

Investigation of antidiabetic activity of Caralumma fibriata
Development of novel animal model for type-2 diabetics model
Evaluation of antidiabetic activity of some Indian medicinal plant

Anticancer Studies:

Phytochemical investigation and evaluation of anticancer activity of Adenoon indicum L. leaves
Development and characterization of anticancer drug loaded erythrocytes membrane vesicles for tumor targeting
Development and evaluation of herbal drug delivery system for chemoprophylaxis of colorectal cancer
Development of capecitabine loaded nanoerythrosomes for colorectal cancer targeting

Anti-Urolithiatic Studies:

Study on antiurolithiatic activity of Sphearanthus indicus Linn
Investigation of antiurolithiatic potential of Annona Squamosa & Citrus sinesis
Investigation of antiurolithiatic activity of Canna indica plant
Phytochemical investigation and pharmacological evaluation of medicinal plant for antiurilithisis

Anti-Hyperlipidemic Studies:

Investigation of antihyperlipidemic activity of Caralumma fibriata
Evaluation of co-crystal of fenofibrate for stability and in-vivo efficacy

Anti-HIV Drug Studies:

Development and evaluation of oral emulsion system for poorly bioavailable Anti-HIV drug

Anti-obesity Studies:

Anti-obesity Studies of a herbal tablet

Pharmacokinetics Study:

Screening potential of polymer some in drug targeting and controlled drug delivery
Development of lipid based topical formulation for antimicrobial activity
Preparation and evaluation of nanoparticulate drug delivery system of certain drug
Development of solid micro-emulsifying drug delivery system of cardiovascular drug for enhance bioavailability
Microencapsulation by spray drying for stability enhancement of rabeprazole
Design and development of mucoadhesive fast disintegrating sublingual tablet for rapid absorption of picroxicam
Disolution rate enhancement and In-Vitro bioavailability study of lornoxicam solid dispersion prepared by spray drying technique
Design, development and characterization of delayed release multiunit particulate system of esmoprazole magnesium
Development of controlled porosity osmotic pump tablet for oral administration of metformin and glipizide
Development of modified release biphasic compressed tablet
Solid self micro-emulsifying drug delivery system of poorly soluble drug for enhancement of bioavailability
Micro-emulsion based in situ gel of ciprifloxacine for ophthalmic drug delivery
Novel solid self micro-emulsifying drug delivery system for enhanced bioavailability of poorly aqueous soluble drug
Screeing natural gum for their potential sustaining release from matrix tablet of Verapamil hydrochloride
Development of solid self micro-emulsifying drug delivery system of ritonavir for bioavailability enhancement
Development of oil in oil emulsion for topical drug delivery of antifungal drug
Development of oro-disersible tablet of atorvastatin calcium using hot melt extrusion
Development of non aqueous emulsion based antiwrinkle formulation containing vitamin C
Development of polyhydroxylic based non aqueous microemulsion for antifungal drug delivery
Quality standardization and toxicity study of Garlicon-A cardivascular formulation
Development and studies on in-vitro, in-vivo correlation of polyhydroxybutyrate based extended release tablet Ibuprofen
Development and studies in in-vitro, in-vivo correlation of new soft gelatin capsule containing oil-in-oil emulsion of Ibuprofen
Development of floating microsphere of antiulcer drug as a gastro-retentive drug delivery system
Development and evaluation of oral emulsion system for poorly bioavailable Anti-HIV drug
Analytical method development for the simultaneous quantification of ternary mixture containing anticonvulsant drugs with biological activity
Formulation, characterization & evaluation of liposomes loaded with biflavonoid and tryptamine derivative for antioxidant activity
Polyacrylic acid docetaxel conjugate micelles: application in tumor targeting
Development and characterization of anticancer drug loaded erythrocytes membrane vesicles for tumor targeting
Development and evaluation of herbal drug delivery system for chemoprophylaxis of colorectal cancer
Evaluation of rectal mucosal irritation study of herbal rectal microbicide
Evaluation of vaginal mucosal irritation study of herbal vaginal microbicide
Study on pharmacokinetics of novel fenofibrate/ atorvastatin nanoformulation in comparison with marketed formulation
Fluvastatin-loaded micelle: role in controlling tumor development and progression
Development of capecitabine loaded nanoerythrosomes for colorectal cancer targeting
Composition of terbinafine HCL nanosuspension for ocular drug delivery
Comparative study of adsorbent carrier and porous polymer: application in improving oral kinetics (Kinetics By HPLC)
Solubilizing agents: Screening for improved oral solubility (Kinetics By HPLC)
Preparation of phospholipid drug complex for improved oral bioavailability (Kinetics By HPLC)